Thymosin Alpha-1
Research Use Only | Not for Human Consumption
A synthetic 28-amino-acid N-terminally acetylated peptide (Tα1) derived from prothymosin alpha, supplied in lyophilized form for laboratory research.
Thymosin Alpha-1 is a synthetic 28-amino-acid, N-terminally acetylated peptide (sequence Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN) originally identified as a fragment of prothymosin alpha produced by the thymus. It is often described as a reference immunomodulatory peptide and has been examined across an extensive body of preclinical, in vitro, and clinical research investigating T-cell maturation and differentiation, Toll-like-receptor and dendritic-cell signaling, natural-killer-cell activity, and cytokine modulation. This material is supplied as a lyophilized powder strictly for laboratory research use only and is not for human consumption.
| CAS# | Formula | Molar Mass |
|---|---|---|
| 62304-98-7 | C₁₂₉H₂₁₅N₃₃O₅₅ | 3108.30 g/mol |
All products are shipped in lyophilized form and must be reconstituted for in-vitro research applications. Refer to the Certificate of Analysis for purity and identity specifications.
A 28-amino-acid thymic peptide studied for immune-signaling and T-cell research
What is Thymosin Alpha-1?
Thymosin Alpha-1 (Tα1) was first isolated in the 1970s from thymosin fraction 5, a thymic tissue extract characterized by the laboratories of Allan Goldstein and colleagues. It was later identified as a 28-amino-acid, N-terminally acetylated fragment of the larger precursor protein prothymosin alpha, and is commonly described as a reference immunomodulatory thymic peptide.
As a research compound, Thymosin Alpha-1 has been the subject of an unusually large published literature spanning immune modulation, viral-infection models such as chronic hepatitis B and C study cohorts, vaccine-adjuvant investigations, sepsis research, and oncology-adjuvant research. Across these studies it has been examined for interactions with T-cell maturation, Toll-like-receptor and dendritic-cell signaling, natural-killer-cell activity, and cytokine networks. (Thymosin Alpha-1 is marketed in some regions under the brand name Zadaxin and is approved as a drug in certain countries; that regulatory status abroad does not imply any intended use of this material, which is supplied for laboratory research only.)
Peptide Foundry supplies Thymosin Alpha-1 as a high-purity lyophilized powder in a 5mg vial for laboratory investigators studying these immune-signaling pathways. This product is intended for research use only and is not for human consumption.
What is Thymosin Alpha-1 studied for?
The following research areas represent documented studies available in the scientific literature. We make no claims regarding the benefits, efficacy, or therapeutic applications of this product.
Immune & T-Cell Signaling Research
In laboratory and clinical research, Thymosin Alpha-1 has been examined for associations with T-cell maturation and differentiation, CD4+/CD8+ subset balance, and immune-cell homeostasis markers in study systems.
TLR & Dendritic-Cell Signaling Research
In preclinical and in vitro studies, Thymosin Alpha-1 has been investigated for interactions with Toll-like receptors (TLR2/TLR9), MyD88-dependent pathways, and dendritic-cell maturation markers.
Antiviral / Viral-Infection-Model Research
In clinical and laboratory research, Thymosin Alpha-1 has been examined in viral-infection models and study cohorts, including chronic hepatitis B and C research populations, for markers of viral replication and immune response.
Inflammation & Sepsis Research
In clinical research and meta-analyses, Thymosin Alpha-1 has been investigated in sepsis and systemic-inflammation study cohorts for associations with cytokine levels (IL-6, TNF-α) and immune-status markers.
How should Thymosin Alpha-1 be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability.
After reconstitution, the peptides will remain stable for up to 30 days.
Certificate of Analysis
All Thymosin Alpha-1 batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
HPLC Purity
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No Certificate of Analysis is available for the selected size yet. Contact support for batch-specific documentation.
COA documents are updated with each new batch. Contact support for batch-specific documentation.
Clinical References
- Camerini R, Garaci E. Historical review of thymosin alpha 1 in infectious diseases. Expert Opin Biol Ther. 2015;15 Suppl 1:S117-27.
- Romani L, Bistoni F, Gaziano R, et al. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling. Blood. 2004;103(11):4232-9.
- You J, Zhuang L, Cheng HY, et al. Efficacy of thymosin alpha-1 and interferon alpha in treatment of chronic viral hepatitis B: a randomized controlled study. World J Gastroenterol. 2006;12(41):6715-21.
- Garaci E, Favalli C, Pica F, et al. Thymosin alpha 1: from bench to bedside. Ann N Y Acad Sci. 2007;1112:225-34.
- Panatto D, Amicizia D, Lai PL, et al. Utility of thymosin alpha-1 (Zadaxin) as a co-adjuvant in influenza vaccines: a review. J Prev Med Hyg. 2011;52(3):111-5.
- Liu D, Yu Z, Yin J, et al. Effect of ulinastatin combined with thymosin alpha1 on sepsis: a systematic review and meta-analysis. J Crit Care. 2016;39:259-266.
