Glutathione
Research Use Only | Not for Human Consumption
A tripeptide composed of glutamate, cysteine, and glycine (γ-glutamyl-cysteinyl-glycine)
Glutathione (GSH) is a naturally occurring reduced tripeptide (γ-glutamyl-cysteinyl-glycine) present in most mammalian cells. It has been examined in preclinical research for its participation in intracellular thiol redox chemistry, glutathione S-transferase conjugation reactions, and GSH/GSSG-dependent signaling.
| CAS# | Formula | Molar Mass |
|---|---|---|
| 70-18-8 | C₁₀H₁₇N₃O₆S | 307.32 g/mol |
All products are shipped in lyophilized form and must be reconstituted for in-vitro research applications. Refer to the Certificate of Analysis for purity and identity specifications.
A tripeptide of glutamate, cysteine, and glycine (γ-glutamyl-cysteinyl-glycine)
What is Glutathione?
Glutathione was first identified in 1888 by French researcher J. de Rey-Pailhade, who isolated the compound from yeast and called it 'philothion.' The name was later changed to glutathione in 1921 when Frederick Hopkins crystallized it and characterized its structure as a tripeptide containing a sulfhydryl group.
Research on glutathione expanded through the mid-20th century as biochemists characterized its distribution across mammalian cell types. Studies documented glutathione synthesis in nearly every cell type, with particularly high concentrations observed in hepatic tissue.
Glutathione has appeared in peer-reviewed publications spanning biochemistry, toxicology, immunology, and cell biology, where it is referenced in research on intracellular redox chemistry and thiol-dependent enzymatic pathways. This product is intended for research use only.
What is Glutathione studied for?
The following research areas represent documented studies available in the scientific literature. We make no claims regarding the benefits, efficacy, or therapeutic applications of this product.
Thiol Redox Chemistry Research
In preclinical models, glutathione has been examined for its cysteine thiol-mediated reduction of reactive oxygen species including hydrogen peroxide, superoxide, and hydroxyl radicals.
View Studies (1)GST Conjugation Research
In vitro studies have observed glutathione's conjugation with electrophilic substrates catalyzed by glutathione S-transferases, forming water-soluble GSH adducts.
View Studies (1)GSH/GSSG Ratio Research
Published investigations have examined the GSH/GSSG ratio as a biochemical marker of intracellular redox state and its associations with protein S-glutathionylation.
View Studies (1)Lymphocyte Thiol Research
Laboratory studies have examined glutathione's associations with intracellular thiol status in cultured lymphocytes and its interactions with thiol-dependent proliferation assays.
View Studies (1)How should Glutathione be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability.
After reconstitution, the peptides will remain stable for up to 30 days.
Certificate of Analysis
All Glutathione batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
HPLC Purity
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No Certificate of Analysis is available for the selected size yet. Contact support for batch-specific documentation.
COA documents are updated with each new batch. Contact support for batch-specific documentation.
Clinical References
- Forman HJ, et al. Glutathione: overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine. 2009.
- Ballatori N, et al. The importance of glutathione in human disease. BioFactors. 2009.
- Dröge W, Breitkreutz R. Glutathione and immune function. Proceedings of the Nutrition Society. 2000.
- Richie JP Jr, et al. Randomized clinical trial of oral glutathione supplementation on body stores of glutathione. European Journal of Nutrition. 2015.
