DSIP
Research Use Only | Not for Human Consumption
A naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit cerebral venous blood
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 62568-57-4 | Molecular Formula: C35H48N10O15 | Molar Mass: 848.81 g/mol |
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A naturally occurring nonapeptide originally isolated from rabbit cerebral venous blood
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, originally isolated from rabbit cerebral venous blood. Published investigations have examined DSIP's interactions with delta-wave sleep EEG patterns, hypothalamic-pituitary-adrenal axis signaling, and oxidative-stress markers in preclinical models.
What is DSIP?
DSIP was first isolated in 1977 by Swiss researchers Schoenenberger and Monnier from the cerebral venous blood of rabbits during electrically induced sleep. They characterized this nonapeptide as a factor associated with delta-wave (slow-wave) EEG patterns, giving it the name Delta Sleep-Inducing Peptide.
Following its discovery, DSIP attracted substantial research interest across multiple fields. Investigations through the 1980s and 1990s examined its interactions with neuroendocrine stress pathways, opioid-system signaling, and oxidative-stress markers. Soviet and later Russian research groups, notably Sudakov and colleagues, contributed extensively to the published literature on DSIP.
DSIP has been identified in various tissues including the hypothalamus, limbic structures, and peripheral blood. Its receptor and precise signaling pathways continue to be investigated, and it has appeared in peer-reviewed preclinical publications examining sleep-regulating neurotransmitter systems, HPA-axis signaling, and oxidative-stress pathways. This product is intended for research use only.
How should DSIP be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Prepared samples must be stored in the fridge to maintain stability, and remain stable for up to 30 days when properly refrigerated.
Certificate of Analysis
All DSIP batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
HPLC Purity
99.178%
Product
DSIP — 5mg
Lot Number
DS31226
Appearance
White Lyophilized Powder
Test Method
HPLC-UV / Mass Spectrometry
Report Date
03/15/2026
COA Number
2603130193
Laboratory
Freedom Diagnostics
No Certificate of Analysis is available for the selected size yet. Contact support for batch-specific documentation.
COA documents are updated with each new batch. Contact support for batch-specific documentation.
References
- Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (sleep)-inducing peptide. Proceedings of the National Academy of Sciences. 1977;74(3):1282-1286. PubMed: 265572
- Sudakov KV, Coghlan JP, Kotov AV, et al. Delta sleep-inducing peptide sequelae: a review of experimental and clinical studies. International Journal of Neuroscience. 1995;83(3-4):235-250.
- Prudchenko IA, Starostina MV, Bhargava KP. Delta sleep-inducing peptide: structure-activity relationships. Peptides. 1995;16(6):1073-1078. PubMed: 8532591
- Lysenko AV, Uskova NI. The mechanisms of DSIP neuroprotective action in conditions of oxidative stress caused by acute emotional stress. Neuroscience and Behavioral Physiology. 2007;37(7):671-675.
