DSIP
Research Use Only | Not for Human Consumption
A naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit cerebral venous blood
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, originally isolated from rabbit cerebral venous blood. Published investigations have examined DSIP's interactions with delta-wave sleep EEG patterns, hypothalamic-pituitary-adrenal axis signaling, and oxidative-stress markers in preclinical models.
| CAS# | Formula | Molar Mass |
|---|---|---|
| 62568-57-4 | C₃₅H₄₈N₁₀O₁₅ | 848.81 g/mol |
All products are shipped in lyophilized form and must be reconstituted for in-vitro research applications. Refer to the Certificate of Analysis for purity and identity specifications.
A naturally occurring nonapeptide originally isolated from rabbit cerebral venous blood
What is DSIP?
DSIP was first isolated in 1977 by Swiss researchers Schoenenberger and Monnier from the cerebral venous blood of rabbits during electrically induced sleep. They characterized this nonapeptide as a factor associated with delta-wave (slow-wave) EEG patterns, giving it the name Delta Sleep-Inducing Peptide.
Following its discovery, DSIP attracted substantial research interest across multiple fields. Investigations through the 1980s and 1990s examined its interactions with neuroendocrine stress pathways, opioid-system signaling, and oxidative-stress markers. Soviet and later Russian research groups, notably Sudakov and colleagues, contributed extensively to the published literature on DSIP.
DSIP has been identified in various tissues including the hypothalamus, limbic structures, and peripheral blood. Its receptor and precise signaling pathways continue to be investigated, and it has appeared in peer-reviewed preclinical publications examining sleep-regulating neurotransmitter systems, HPA-axis signaling, and oxidative-stress pathways. This product is intended for research use only.
What is DSIP studied for?
The following research areas represent documented studies available in the scientific literature. We make no claims regarding the benefits, efficacy, or therapeutic applications of this product.
Delta-Wave EEG Research
In preclinical EEG studies, DSIP has been examined for its association with delta-wave (slow-wave) activity and sleep-stage transitions in rodent and rabbit models.
HPA-Axis Signaling Research
In laboratory studies, DSIP has been investigated for its interactions with ACTH and corticosterone release along the hypothalamic-pituitary-adrenal axis.
Oxidative-Stress Pathway Research
In preclinical models, DSIP has been studied for its associations with antioxidant-enzyme activity and neuronal markers under oxidative-stress conditions.
Neuroendocrine Signaling Research
In vitro and in vivo investigations have examined DSIP's interactions with hypothalamic-pituitary signaling and peptide-hormone release profiles.
Lipid-Peroxidation Marker Research
Laboratory studies have observed DSIP's associations with free-radical scavenging activity and lipid-peroxidation markers in neural-tissue preparations.
Opioid-Receptor Signaling Research
In preclinical studies, DSIP has been examined for its interactions with endogenous opioid systems and met-enkephalin levels in nociceptive-pathway models.
How should DSIP be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability.
After reconstitution, the peptides will remain stable for up to 30 days.
Certificate of Analysis
All DSIP batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
HPLC Purity
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No Certificate of Analysis is available for the selected size yet. Contact support for batch-specific documentation.
COA documents are updated with each new batch. Contact support for batch-specific documentation.
Clinical References
- Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (sleep)-inducing peptide. Proceedings of the National Academy of Sciences. 1977;74(3):1282-1286. PubMed: 265572
- Sudakov KV, Coghlan JP, Kotov AV, et al. Delta sleep-inducing peptide sequelae: a review of experimental and clinical studies. International Journal of Neuroscience. 1995;83(3-4):235-250.
- Prudchenko IA, Starostina MV, Bhargava KP. Delta sleep-inducing peptide: structure-activity relationships. Peptides. 1995;16(6):1073-1078. PubMed: 8532591
- Lysenko AV, Uskova NI. The mechanisms of DSIP neuroprotective action in conditions of oxidative stress caused by acute emotional stress. Neuroscience and Behavioral Physiology. 2007;37(7):671-675.
