Epithalon
Research Use Only | Not for Human Consumption
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin, supplied in lyophilized form.
Epithalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, originally derived from epithalamin, a pineal gland extract. It has been examined in preclinical and in vitro research investigating telomerase enzyme activity, chromosomal telomere dynamics, and gene-expression patterns in cultured cell lines.
| CAS# | Formula | Molar Mass |
|---|---|---|
| 307297-39-8 | C₁₄H₂₂N₄O₉ | 390.35 g/mol |
All products are shipped in lyophilized form and must be reconstituted for in-vitro research applications. Refer to the Certificate of Analysis for purity and identity specifications.
A synthetic tetrapeptide developed at the St. Petersburg Institute of Bioregulation and Gerontology
What is Epithalon?
Epithalon was developed in the former Soviet Union during the 1980s by Professor Vladimir Khavinson, whose laboratory was investigating the biochemistry of the pineal gland. Khavinson's group was characterizing how pineal-derived peptide fractions changed across different research models.
From pineal gland extracts, Khavinson's team isolated a peptide fraction named epithalamin. To produce a defined, reproducible research compound, the group synthesized a simpler four-amino-acid sequence (Ala-Glu-Asp-Gly) and designated it Epithalon.
The peptide has since been examined in preclinical and in vitro publications exploring telomerase enzyme activity and chromosomal telomere measurements. This product is intended for research use only.
What is Epithalon studied for?
The following research areas represent documented studies available in the scientific literature. We make no claims regarding the benefits, efficacy, or therapeutic applications of this product.
Telomerase Enzyme Research
In in vitro studies, Epithalon has been examined for interactions with telomerase (hTERT) enzyme activity and telomeric repeat measurements in cultured human somatic cells.
View Studies (1)Neuronal Pathway Research
In preclinical models, Epithalon has been investigated for associations with neuronal oxidative stress markers and synaptic signaling proteins.
View Studies (1)Oxidative Stress Marker Research
In preclinical studies, Epithalon has been examined for effects on lipid peroxidation markers and endogenous antioxidant enzyme activity, including SOD and catalase.
View Studies (1)Pineal & Melatonin Pathway Research
In animal-model research, Epithalon has been studied for associations with pineal melatonin secretion profiles and circadian signaling markers.
View Studies (1)Cardiac Marker Research
In preclinical models, Epithalon has been examined for associations with cardiac function markers and vascular biomarker parameters.
View Studies (1)Oncogene Expression Research
In preclinical rodent models, Epithalon has been investigated for observations related to spontaneous tumor incidence and oncogene expression patterns.
View Studies (1)How should Epithalon be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability.
After reconstitution, the peptides will remain stable for up to 30 days.
Certificate of Analysis
All Epithalon batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
HPLC Purity
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No Certificate of Analysis is available for the selected size yet. Contact support for batch-specific documentation.
COA documents are updated with each new batch. Contact support for batch-specific documentation.
Clinical References
- Khavinson VKh, et al. Epitalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. 2003.
- Anisimov VN, et al. Effect of Epithalon on biomarkers of aging, life span and spontaneous tumor incidence in female mice. Biogerontology. 2002.
- Korkushko OV, et al. Peptide preparation Epithalamin increases the lifespan and inhibits spontaneous tumor development in female rats. Biogerontology. 2006.
- Khavinson VKh, et al. Effect of epithalon on the lifespan increase in Drosophila melanogaster. Mechanisms of Ageing and Development. 2000.
