AOD-9604
Research Use Only | Not for Human Consumption
A synthetic 16-amino-acid fragment corresponding to residues 176–191 of the C-terminus of human growth hormone
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 221231-10-3 | Molecular Formula: C78H123N23O23S2 | Molar Mass: 1815.08 g/mol |
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A synthetic fragment of human growth hormone (residues 176–191)
AOD-9604 is a synthetic fragment of the C-terminus of human growth hormone (HGH), corresponding to amino acids 176–191. It has been examined in preclinical models for interactions with lipolytic signaling pathways distinct from the glycemic and growth-promoting pathways associated with full-length HGH.
What is AOD-9604?
AOD-9604 was developed in the late 1990s at Monash University in Australia. Researchers there were investigating whether a fragment of the growth hormone molecule could retain lipolytic signaling activity in adipocyte models without the glycemic and proliferative effects of the full-length protein.
The team identified that amino acids 176 to 191 of the growth hormone sequence exhibited lipolytic signaling in adipose tissue models without activating insulin or IGF-1-related growth pathways. They designated this fragment AOD-9604.
AOD-9604 has appeared in peer-reviewed preclinical publications examining growth-hormone fragment biology and adipocyte signaling since the early 2000s. This product is intended for research use only.
How should AOD-9604 be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Prepared samples must be stored in the fridge to maintain stability, and remain stable for up to 30 days when properly refrigerated.
Certificate of Analysis
Every batch of AOD-9604 is tested by ILS Laboratories, an ISO/IEC 17025–accredited lab, for purity, identity, heavy metals, sterility, endotoxin, and a fentanyl screen. The full certificate is below.
AOD-9604 · 5mg
Peptide Purity · HPLC @ 214 nm
99.49% — exceptional research-grade purity
Area-normalized against all peptide-related peaks. Identity confirmed by chromatographic retention-time match to a reference standard.
Every test on this certificate
COA documents are updated with each new batch. Contact support for batch-specific documentation.
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References
- Heffernan MA, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and u03b23-AR knock-out mice. Endocrinology. 2001;142(12):5182-5189. PubMed: 11713213
- Ng FM, et al. Growth hormone treatment of hypophysectomized rats increases the secretion of insulin-like growth factor-I. Endocrinology. 2000;141(8):3098-3103. PubMed: 10965879
- Munro S, et al. AOD9604, a synthetic lipolytic peptide with high receptor binding affinity and in vivo efficacy. International Journal of Obesity. 2006;30(8):1217-1224.
