MOTS-C
Research Use Only | Not for Human Consumption
A 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 1627580-64-6 | Molecular Formula: C101H152N28O22S2 | Molar Mass: 2174.6 g/mol |
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A 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-C) is a 16-amino-acid mitochondrial-derived peptide (MDP). It has been examined in preclinical models of AMPK signaling and mitochondria-to-nucleus retrograde communication.
What is MOTS-C?
MOTS-C was first described in 2015 by Dr. Pinchas Cohen and his research team at the University of Southern California's Leonard Davis School of Gerontology. The characterization identified a short open reading frame within the mitochondrial 12S rRNA gene encoding a distinct peptide, adding to an emerging class of mitochondrial-derived peptides.
The peptide's name reflects its origin: MOTS-C stands for Mitochondrial Open Reading Frame of the 12S rRNA type-C. It is a 16-amino-acid sequence encoded within a region of mitochondrial DNA previously considered non-coding. Its characterization contributed to an ongoing research field focused on mitochondrial-derived peptides (MDPs) and mitochondria-to-nucleus signaling.
Published observational research has reported measurements of circulating MOTS-C concentrations. Preclinical studies in murine models have examined MOTS-C's interactions with AMPK signaling, insulin-signaling components, and lipid-metabolism pathways. This product is intended for research use only.
How should MOTS-C be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Prepared samples must be stored in the fridge to maintain stability, and remain stable for up to 30 days when properly refrigerated.
Certificate of Analysis
Every batch of MOTS-C is tested by ILS Laboratories, an ISO/IEC 17025–accredited lab, for purity, identity, heavy metals, sterility, endotoxin, and a fentanyl screen. The full certificate is below.
MOTS-C · 10mg
Peptide Purity · HPLC @ 214 nm
99.71% — exceptional research-grade purity
Area-normalized against all peptide-related peaks. Identity confirmed by chromatographic retention-time match to a reference standard.
Every test on this certificate
COA documents are updated with each new batch. Contact support for batch-specific documentation.
References
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. 2015;21(3):443-454. PubMed: 25738459
- Kim KH, et al. MOTS-c: A mitochondrial-encoded regulator of the nucleus during metabolic stress. Journal of the American Society of Nephrology. 2018;29(10):2367-2369. PubMed: 29983246
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. 2021;12(1):470. PubMed: 33473109
