GHK-CU
Research Use Only | Not for Human Consumption
A copper-binding tripeptide composed of glycine, histidine, and lysine bound to a copper ion; supplied in lyophilized form.
A synthetic copper-binding tripeptide (Gly-His-Lys) complexed with copper(II). Has appeared in peer-reviewed preclinical publications examining fibroblast gene expression, copper-dependent enzymatic cofactor activity, and extracellular matrix protein synthesis in cell culture models.
| CAS# | Formula | Molar Mass |
|---|---|---|
| 49557-75-7 | C₁₄H₂₂CuN₆O₄ | 401.91 g/mol |
All products are shipped in lyophilized form and must be reconstituted for in-vitro research applications. Refer to the Certificate of Analysis for purity and identity specifications.
A naturally occurring copper-binding tripeptide first identified in human blood plasma in the 1970s
What is GHK-CU?
GHK-Cu was first characterized by Dr. Loren Pickart in 1973 while he was studying human blood plasma at the University of Washington. His laboratory work compared biochemical activity between plasma samples from different age cohorts and isolated a small copper-binding peptide that appeared to account for differences observed in the assays.
The peptide was three amino acids long—glycine, histidine, and lysine—bound to a copper ion. Dr. Pickart designated it GHK-Cu. Subsequent observational research reported that plasma GHK concentrations varied across age groups, which prompted further laboratory investigation of the molecule.
Over the following decades, published research on GHK-Cu expanded across fibroblast biology, copper-enzyme biochemistry, and gene-expression profiling, with genomic analyses reporting modulation of several thousand genes in cultured cells. GHK-Cu has appeared in peer-reviewed preclinical publications since the 1970s. This product is intended for research use only.
What is GHK-CU studied for?
The following research areas represent documented studies available in the scientific literature. We make no claims regarding the benefits, efficacy, or therapeutic applications of this product.
Collagen Synthesis Research
In vitro studies have examined GHK-Cu's associations with type I, III, and IV collagen mRNA expression and glycosaminoglycan production in fibroblast cultures.
View Studies (1)SOD & Cytokine Pathway Research
Laboratory studies have examined GHK-Cu's interactions with superoxide dismutase cofactor activity and expression of TNF-α, IL-1β, and IL-6 in cell culture.
View Studies (1)Fibroblast & ECM Research
Preclinical cell-culture research has observed GHK-Cu's associations with fibroblast proliferation, angiogenesis markers, and dermal matrix protein expression.
View Studies (1)Neuronal Cell Culture Research
In vitro studies using neuronal cell models have examined GHK-Cu's interactions with oxidative-stress markers and neuroinflammatory signaling proteins.
View Studies (1)Follicle Cell Biology Research
Preclinical studies have examined GHK-Cu's associations with follicular dermal papilla cell morphology and Wnt/β-catenin pathway expression in vitro.
View Studies (1)Gene Expression Research
Genomic analyses have examined GHK-Cu's associations with expression profiles of genes involved in extracellular matrix assembly, inflammation, and cellular senescence.
View Studies (1)How should GHK-CU be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability.
After reconstitution, the peptides will remain stable for up to 30 days.
Certificate of Analysis
All GHK-CU batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
HPLC Purity
—
No Certificate of Analysis is available for the selected size yet. Contact support for batch-specific documentation.
COA documents are updated with each new batch. Contact support for batch-specific documentation.
Related Research Compounds
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Clinical References
- Pickart L. The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition. 2008.
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences. 2018.
- Pickart L, et al. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International. 2015.
- Pollard JD, et al. Stimulation of collagen production in fibroblast cultures by the tripeptide-copper complex GHK-Cu. Archives of Facial Plastic Surgery. 2005.
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