NAD+
Research Use Only | Not for Human Consumption
A buffered form of nicotinamide adenine dinucleotide, a coenzyme naturally present in every living cell
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 53-84-9 | Molecular Formula: C21H27N7O14P2 | Molar Mass: 663.4 g/mol |
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A buffered form of nicotinamide adenine dinucleotide
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme that has been characterized in biochemical research since the early 1900s. This buffered formulation is supplied in lyophilized form for preclinical research examining NAD+-dependent enzymatic pathways, including sirtuin deacetylation, PARP-mediated reactions, and mitochondrial redox chemistry.
What is NAD+?
NAD+ was first identified in 1906 by Arthur Harden and William John Young while studying fermentation in yeast extracts. They observed that adding boiled yeast extract to unboiled extract altered the rate of fermentation—the heat-stable factor they characterized was later recognized as NAD+.
The molecule's role in metabolism was elaborated over the following decades. Hans von Euler-Chelpin received the 1929 Nobel Prize for elucidating NAD's structure and function. NAD+ participates in over 500 enzymatic reactions and serves as a cofactor for enzymes that transfer electrons during cellular respiration and related biochemical processes.
In the early 2000s, published research characterized NAD+ as a required substrate for sirtuin enzymes, a family of deacetylases described in multiple model organisms. Subsequent preclinical research has examined age-associated changes in NAD+ levels and the enzymatic pathways that consume and regenerate it. This buffered formulation maintains pH stability for research applications. This product is intended for research use only.
How should NAD+ be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Prepared samples must be stored in the fridge to maintain stability, and remain stable for up to 30 days when properly refrigerated.
Certificate of Analysis
Every batch of NAD+ is tested by Freedom Diagnostics for purity, identity, heavy metals, sterility, and endotoxin. The full certificate is below.
NAD+ · 1000mg
Peptide Purity · HPLC @ 214 nm
99.94% — exceptional research-grade purity
Area-normalized against all peptide-related peaks. Identity confirmed by chromatographic retention-time match to a reference standard.
Every test on this certificate
COA documents are updated with each new batch. Contact support for batch-specific documentation.
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References
- Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213. PubMed: 26785480
- Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464-471. PubMed: 24786309
- Yoshino J, et al. NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism. 2018;27(3):513-528. PubMed: 29249689
