NAD+

NAD+

$65.00

Research Use Only | Not for Human Consumption

A buffered form of nicotinamide adenine dinucleotide, a coenzyme naturally present in every living cell

Published February 4, 2026 · Reviewed by the Peptide Foundry Research Team

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme that has been characterized in biochemical research since the early 1900s. This buffered formulation is supplied in lyophilized form for preclinical research examining NAD+-dependent enzymatic pathways, including sirtuin deacetylation, PARP-mediated reactions, and mitochondrial redox chemistry.

CAS#FormulaMolar Mass
53-84-9C₂₁H₂₇N₇O₁₄P₂663.4 g/mol

All products are shipped in lyophilized form and must be reconstituted for in-vitro research applications. Refer to the Certificate of Analysis for purity and identity specifications.

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A buffered form of nicotinamide adenine dinucleotide

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What is NAD+?

NAD+ was first identified in 1906 by Arthur Harden and William John Young while studying fermentation in yeast extracts. They observed that adding boiled yeast extract to unboiled extract altered the rate of fermentationu2014the heat-stable factor they characterized was later recognized as NAD+.

The molecule's role in metabolism was elaborated over the following decades. Hans von Euler-Chelpin received the 1929 Nobel Prize for elucidating NAD's structure and function. NAD+ participates in over 500 enzymatic reactions and serves as a cofactor for enzymes that transfer electrons during cellular respiration and related biochemical processes.

In the early 2000s, published research characterized NAD+ as a required substrate for sirtuin enzymes, a family of deacetylases described in multiple model organisms. Subsequent preclinical research has examined age-associated changes in NAD+ levels and the enzymatic pathways that consume and regenerate it. This buffered formulation maintains pH stability for research applications. This product is intended for research use only.

What is NAD+ studied for?

The following research areas represent documented studies available in the scientific literature. We make no claims regarding the benefits, efficacy, or therapeutic applications of this product.

Mitochondrial Redox Research

In preclinical models, NAD+ has been examined as an electron-accepting cofactor in oxidative phosphorylation and the electron transport chain.

Sirtuin Pathway Research

In laboratory studies, NAD+ has been investigated as a required substrate for SIRT1u2013SIRT7 deacetylation reactions.

PARP & DNA-Damage Research

In vitro research has examined NAD+ as the substrate consumed by PARP enzymes during poly(ADP-ribose) formation at DNA damage sites.

Neuronal Metabolism Research

Published preclinical research has examined NAD+ levels in neuronal cell models and rodent studies of neurodegeneration-related pathways.

Glycolysis & TCA-Cycle Research

In vitro investigations have characterized NAD+/NADH as a cofactor pair in glycolysis, the citric acid cycle, and oxidative phosphorylation.

CD38 & NAD+ Consumption Research

Preclinical studies have examined NAD+'s interactions with CD38, an NAD+-consuming ectoenzyme studied in aging-related research models.

How should NAD+ be stored?

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.

Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability.

After reconstitution, the peptides will remain stable for up to 30 days.

Certificate of Analysis

All NAD+ batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.

HPLC Purity

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COA documents are updated with each new batch. Contact support for batch-specific documentation.

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Clinical References

  1. Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213. PubMed: 26785480
  2. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464-471. PubMed: 24786309
  3. Yoshino J, et al. NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism. 2018;27(3):513-528. PubMed: 29249689

NAD+ is available for laboratory research purposes only.

© 2026 Peptide Foundry LLC | Product Catalog | Research Use Only

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Disclaimer: -Peptides: This product is intended for laboratory research use only and is not approved for human consumption, medical, or veterinary use. Peptides are sold solely for research and development purposes by qualified professionals. Buyers are responsible for handling all materials in accordance with local regulations and safety guidelines. Waave Compliance blocks all international shipping. FDA disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure, or prevent any disease.