IGF-1 LR3
Research Use Only | Not for Human Consumption
A modified analog of human Insulin-like Growth Factor-1 with a 13-amino-acid N-terminal extension and an arginine substitution at position 3
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 946870-92-4 | Molecular Formula: C400H625N111O115S9 | Molar Mass: 9117.6 g/mol |
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A modified IGF-1 analog with a 13-amino-acid N-terminal extension and Arg-3 substitution
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a recombinant analog of human IGF-1. The 'Long' refers to a 13-amino-acid extension at the N-terminus, and 'R3' indicates an arginine substitution at position 3, a modification that reduces affinity for IGF-binding proteins in preclinical research models. Supplied in lyophilized form.
What is IGF-1 LR3?
IGF-1 LR3 emerged from research efforts in the late 1980s and early 1990s to create modified versions of insulin-like growth factor with altered binding profiles. Scientists at GroPep in Adelaide, Australia, were among the first to develop this modified peptide, characterizing it in the context of native IGF-1's rapid sequestration by circulating binding proteins.
The key structural change was twofold: adding 13 extra amino acids to the N-terminus of the peptide sequence and substituting arginine for glutamic acid at position 3. These modifications reduced affinity for IGF-binding proteins (IGFBPs) in preclinical assays, yielding a research-grade analog with a longer apparent half-life in in-vitro and animal models than native IGF-1.
Since its development, IGF-1 LR3 has appeared in peer-reviewed preclinical publications examining IGF-1 receptor signaling in cell culture and animal models. Its reduced IGFBP affinity makes it a common tool compound for investigating IGF-1R-mediated pathways in research settings. This product is intended for research use only.
How should IGF-1 LR3 be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Prepared samples must be stored in the fridge to maintain stability, and remain stable for up to 30 days when properly refrigerated.
Certificate of Analysis
All IGF-1 LR3 batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
HPLC Purity
98.509%
Product
IGF-1 LR3 — 1mg
Lot Number
IG312
Appearance
White Lyophilized Powder
Test Method
HPLC-UV / Mass Spectrometry
Report Date
03/15/2026
COA Number
2603130190
Laboratory
Freedom Diagnostics
No Certificate of Analysis is available for the selected size yet. Contact support for batch-specific documentation.
COA documents are updated with each new batch. Contact support for batch-specific documentation.
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References
- Francis GL, et al. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. Journal of Molecular Endocrinology. 1992;8(3):213-223. PubMed: 1378742
- Tomas FM, et al. Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. Biochemical Journal. 1992;282(Pt 1):91-97. PubMed: 1371669
- Ballard FJ, et al. Does IGF-I ever act through the insulin receptor? Cytokine & Growth Factor Reviews. 2007;18(1-2):7-12.
