Semax
Research Use Only | Not for Human Consumption
A synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-10) fragment; supplied in lyophilized form.
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 80714-61-0 | Molecular Formula: C37H51N9O10S | Molar Mass: 813.9 g/mol |
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A synthetic heptapeptide derived from a fragment of the natural ACTH hormone.
Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone fragment ACTH(4-10) with a C-terminal Pro-Gly-Pro extension. Published preclinical investigations have examined its interactions with BDNF and NGF gene expression, melanocortin receptor binding, and monoaminergic signaling in rodent and in vitro models.
What is Semax?
Semax was developed in the 1980s at the Institute of Molecular Genetics of the Russian Academy of Sciences by a team led by Nikolai Myasoedov and Isaak Ashmarin. The researchers were investigating fragments of adrenocorticotropic hormone (ACTH) that retained neurotropic activity without the hormonal effects on the adrenal glands.
The ACTH(4-10) fragment studied by the group was rapidly degraded in preclinical models. By adding a Pro-Gly-Pro tripeptide to the C-terminus—the same modification later used in Selank—they produced a heptapeptide with improved stability characteristics in published assays.
Semax has been the subject of extensive preclinical investigation in Russia since the early 1990s. Published research has examined its interactions with BDNF and NGF signaling, melanocortin receptors, and monoaminergic pathways. This product is intended for research use only.
How should Semax be stored?
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Prepared samples must be stored in the fridge to maintain stability, and remain stable for up to 30 days when properly refrigerated.
Certificate of Analysis
Every batch of Semax is tested by ILS Laboratories, an ISO/IEC 17025–accredited lab, for purity, identity, heavy metals, sterility, endotoxin, and a fentanyl screen. The full certificate is below.
Semax · 10mg
Peptide Purity · HPLC @ 214 nm
99.62% — exceptional research-grade purity
Area-normalized against all peptide-related peaks. Identity confirmed by chromatographic retention-time match to a reference standard.
Every test on this certificate
COA documents are updated with each new batch. Contact support for batch-specific documentation.
References
- Ashmarin IP, et al. The nootropic drug Semax: a review of its mechanisms of action. Neuroscience and Behavioral Physiology. 2005.
- Dolotov OV, et al. Semax regulates BDNF and trkB expression in the rat hippocampus. Brain Research. 2006. PubMed: 16996037
- Gusev EI, et al. Semax in prevention of disease progress in patients with cerebrovascular insufficiency. Zhurnal Nevrologii i Psikhiatrii. 2005.
- Agapova TY, et al. Effects of Semax on dopamine and serotonin metabolism in rat brain. Doklady Biological Sciences. 2007.
