PT-141
Research Use Only · Not for Human Consumption
A synthetic cyclic heptapeptide analog of alpha-MSH, supplied in lyophilized form.
A synthetic melanocortin receptor agonist peptide
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 189691-06-3 | Molecular Formula: C50H68N14O10 | Molar Mass: 1025.2 g/mol |
What is PT-141?
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide derived from alpha-melanocyte-stimulating hormone. In preclinical research, it has been examined as an agonist of melanocortin receptors, with a focus on MC4R binding and downstream intracellular signaling in neuronal cell models.
PT-141, also called Bremelanotide, originated from Melanotan 2 research at the University of Arizona. Scientists there were characterizing melanocortin receptor analogs and observed MC4R-mediated signaling activity distinct from the melanogenesis pathways that were the original focus of investigation.
Researchers subsequently modified the Melanotan 2 structure to produce a cyclic heptapeptide with altered receptor selectivity. The resulting compound, PT-141, has since appeared in peer-reviewed preclinical publications examining melanocortin receptor binding and central nervous system signaling.
In preclinical models, Bremelanotide has been examined for its melanocortin receptor pharmacology. The research-grade form is used in melanocortin receptor signaling studies. This product is intended for research use only and is not for human consumption.
How should PT-141 be stored?
Peptide Foundry research peptides are supplied lyophilized (freeze-dried). Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution.
Certificate of Analysis
All PT-141 batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
HPLC Purity
99.872%
Product
PT-141 — 10mg
Lot Number
PT312
Appearance
White Lyophilized Powder
Measured Net Content
9.09 mg
Test Method
HPLC-UV / Mass Spectrometry
Report Date
03/15/2026
COA Number
2603130191
Laboratory
Freedom Diagnostics
No Certificate of Analysis is available for the selected size yet. Contact support for batch-specific documentation.
COA documents are updated with each new batch. Contact support for batch-specific documentation.
Related Research Compounds
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Further reading
References
- Pfaus JG, et al. Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proceedings of the National Academy of Sciences. 2004.
