Tesamorelin
Research Use Only · Not for Human Consumption
A synthetic 44-amino-acid analog of human growth hormone-releasing hormone (GHRH) with a trans-3-hexenoic acid modification at Tyr1
A 44-amino-acid GHRH analog with a trans-3-hexenoic acid modification; CAS 218949-48-5
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 218949-48-5 | Molecular Formula: C221H366N72O67S | Molar Mass: 5135.9 g/mol |
What is Tesamorelin?
A synthetic GHRH analog stabilized by an N-terminal trans-3-hexenoic acid group that resists enzymatic degradation. Published preclinical research has examined its interactions with the pituitary GHRH receptor (GHRHR) and downstream somatotroph signaling pathways.
Tesamorelin was developed in the early 2000s by Theratechnologies, a Canadian pharmaceutical company based in Montreal. The research team worked on analogs of growth hormone-releasing hormone (GHRH), building on earlier structural work with the native 44-amino-acid peptide.
The molecule is distinguished by a trans-3-hexenoic acid group attached to the tyrosine at position 1. In preclinical characterization, this modification resists enzymatic breakdown while preserving receptor-binding activity of the parent GHRH sequence.
The compound has since appeared in published preclinical investigations of the GHRH receptor (GHRHR) and associated somatotroph signaling pathways. This product is intended for research use only.
How should Tesamorelin be stored?
Peptide Foundry research peptides are supplied lyophilized (freeze-dried). Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution.
Certificate of Analysis
Every batch of Tesamorelin is tested by Freedom Diagnostics for purity, identity, heavy metals, sterility, and endotoxin. The full certificate is below.
Tesamorelin · 10mg
Peptide Purity · HPLC @ 214 nm
99.79% — exceptional research-grade purity
Area-normalized against all peptide-related peaks. Identity confirmed by chromatographic retention-time match to a reference standard.
Every test on this certificate
COA documents are updated with each new batch. Contact support for batch-specific documentation.
Related Research Compounds
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Further reading
References
- Falutz J, et al. New England Journal of Medicine. 2007. PubMed: 18057338
- Stanley TL, et al. JAMA. 2014. PubMed: 25038357
- Falutz J, et al. Journal of Clinical Endocrinology & Metabolism. 2007. PubMed: 20101189
- Makimura H, et al. Journal of Clinical Endocrinology & Metabolism. 2015.
