Selank
Research Use Only · Not for Human Consumption
A synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from tuftsin, supplied in lyophilized form.
A synthetic heptapeptide derived from the natural immune peptide tuftsin.
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 129954-34-3 | Molecular Formula: C33H57N11O9 | Molar Mass: 751.9 g/mol |
What is Selank?
A synthetic heptapeptide derived from the immunomodulatory tetrapeptide tuftsin by addition of a C-terminal Pro-Gly-Pro sequence. Selank has been examined in preclinical models of GABAergic signaling, monoamine metabolism, and tuftsin-related immunomodulatory pathways.
Selank was developed in the late 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences, under the direction of Nikolai Myasoedov. The research team was exploring derivatives of tuftsin, an immunomodulatory tetrapeptide naturally present in the body as part of the immunoglobulin G heavy chain.
The scientists added a Pro-Gly-Pro sequence to tuftsin, producing a heptapeptide with greater metabolic stability. In preclinical characterization work, the modified molecule retained tuftsin-associated immunomodulatory activity and was also observed to influence central-nervous-system endpoints in rodent assays.
Selank has been the subject of extensive preclinical investigation since its development, with published research examining GABAergic signaling, monoamine metabolism, immunomodulatory activity, and neurotrophic-factor expression. This product is intended for research use only.
How should Selank be stored?
Peptide Foundry research peptides are supplied lyophilized (freeze-dried). Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution.
Certificate of Analysis
Every batch of Selank is tested by ILS Laboratories, an ISO/IEC 17025–accredited lab, for purity, identity, heavy metals, sterility, endotoxin, and a fentanyl screen. The full certificate is below.
Selank · 10mg
Peptide Purity · HPLC @ 214 nm
99.46% — exceptional research-grade purity
Area-normalized against all peptide-related peaks. Identity confirmed by chromatographic retention-time match to a reference standard.
Every test on this certificate
COA documents are updated with each new batch. Contact support for batch-specific documentation.
Further reading
References
- Seredenin SB, et al. Anxiolytic action of the synthetic peptide Selank. Bulletin of Experimental Biology and Medicine. 1998.
- Kozlovskii II, et al. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neuroscience and Behavioral Physiology. 2003. PubMed: 14969422
- Zozulia AA, et al. Effects of Selank on the immunity status in patients with generalized anxiety disorder. Zhurnal Nevrologii i Psikhiatrii. 2008.
