Sermorelin
A 29-amino-acid GHRH analog studied in laboratory settings for growth hormone releasing activity and pituitary function
About Sermorelin
Sermorelin (CAS 86168-78-7) is a synthetic peptide corresponding to the first 29 amino acids of human growth hormone-releasing hormone (GHRH 1-29). It represents the shortest fully functional fragment of GHRH shown in preclinical research to retain GHRH receptor binding activity comparable to the full-length 44-amino acid peptide.
Sermorelin emerged from groundbreaking research in the late 1970s and early 1980s when scientists were racing to understand how the brain controls growth hormone release. The pivotal discovery came in 1982 when Roger Guillemin's team at the Salk Institute in California isolated and characterized the structure of growth hormone-releasing hormone from pancreatic tumors.
Researchers quickly determined that the first 29 amino acids of the 44-amino acid GHRH molecule were sufficient for full biological activity. This truncated version, named Sermorelin (or GHRH 1-29), became the standard for research because it was easier and more economical to synthesize while maintaining identical receptor binding and signaling properties.
Sermorelin became one of the first GHRH analogs to be extensively studied in clinical settings during the 1990s. Its relatively short half-life made it valuable for research into pulsatile GH release patterns. Today, it remains one of the most widely used peptides in growth hormone axis research due to its well-characterized pharmacology.
Quick Facts
| CAS Number | 86168-78-7 |
|---|---|
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Molar Mass | 3357.9 g/mol |
| Sequence | 29 amino acids (GHRH 1-29) |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC verified) |
| Third-Party Testing | Freedom Diagnostics (COA included) |
| Storage | Room temp 3–4 months; refrigerate post-reconstitution |
| Price (from) | $110.00 USD |
| SKU | PF-SERM-10MG |
How Sermorelin Works
Preclinical studies have examined Sermorelin's mechanism as the minimal active fragment of GHRH that binds to pituitary GHRH receptors to stimulate endogenous growth hormone synthesis and pulsatile release.
GHRH Receptor Activation
Sermorelin binds to GHRH receptors (GHRHR) on pituitary somatotroph cells with affinity equivalent to full-length GHRH. The receptor is a G protein-coupled receptor that initiates intracellular signaling upon ligand binding.
cAMP Signaling Cascade
GHRHR activation couples to Gs proteins, stimulating adenylyl cyclase and elevating intracellular cAMP. This activates protein kinase A (PKA), leading to CREB phosphorylation and enhanced GH gene transcription.
Calcium-Dependent Release
cAMP signaling also opens voltage-gated calcium channels, increasing intracellular calcium concentrations. This calcium influx triggers exocytosis of stored GH-containing secretory granules from somatotrophs.
Preserved Feedback Regulation
Unlike exogenous GH, Sermorelin preserves natural negative feedback mechanisms. Elevated GH and IGF-1 levels appropriately suppress further GHRH responsiveness, maintaining physiological regulation.
Frequently Asked Questions
- What is Sermorelin?
- Sermorelin (CAS 86168-78-7) is a synthetic peptide corresponding to the first 29 amino acids of human growth hormone-releasing hormone (GHRH 1-29). It represents the shortest fully functional fragment of GHRH shown in preclinical research to retain GHRH receptor binding activity comparable to the full-length 44-amino acid peptide.
- What is the CAS number for Sermorelin?
- The CAS number for Sermorelin is 86168-78-7.
- What purity is Peptide Foundry's Sermorelin?
- Peptide Foundry's research peptides are manufactured to 99%+ purity. Every batch is verified by an independent third-party laboratory (Freedom Diagnostics) using high-performance liquid chromatography (HPLC) for purity and identity, Limulus amebocyte lysate (LAL) assay for bacterial endotoxin, and inductively coupled plasma mass spectrometry (ICP-MS) for heavy-metal contamination. A Certificate of Analysis is published for every product and batch.
- How should Sermorelin be stored?
- Lyophilized (freeze-dried) peptides are stable at room temperature for 3–4 months. Once reconstituted with bacteriostatic water, store refrigerated (2–8 °C) and use within 30 days. Keep away from direct light and extreme temperatures.
- Does Sermorelin ship with a Certificate of Analysis?
- Yes. Every batch of every product ships with a Certificate of Analysis from Freedom Diagnostics, an independent third-party analytical laboratory. The COA documents HPLC purity, peptide identity, endotoxin testing, and heavy-metals screening.
- Is Sermorelin sold for human use?
- No. All products sold by Peptide Foundry are strictly for in-vitro research and laboratory use only (RUO). They are not intended for human or animal consumption, therapeutic use, or diagnostic application.
Scientific References
- Corpas E, et al. Growth hormone-releasing hormone and growth hormone secretagogues in clinical and experimental therapeutics. Hormone Research. 1993.
- Vittone J, et al. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism. 1997. PubMed: 9005976
- Steiger A, et al. Growth hormone-releasing hormone improves the quality of sleep. Experimental and Clinical Endocrinology & Diabetes. 1995.
- Walker RF. Sermorelin: A better approach to management of adult-onset growth hormone insufficiency? Clinical Interventions in Aging. 2006. PubMed: 18046908
This product is sold strictly for in-vitro research use only (RUO). It is not intended for human or animal consumption, therapeutic use, or diagnostic application.