Semax
A synthetic ACTH(4-10) analog studied in laboratory settings for neuroprotection and cognitive enhancement
About Semax
Semax (CAS 80714-61-0) is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4-10), studied in laboratory settings for its interactions with neurotrophic signaling pathways and neuroprotective mechanisms in preclinical models.
Semax was developed in the 1980s at the Institute of Molecular Genetics of the Russian Academy of Sciences by a team led by Nikolai Myasoedov and Isaak Ashmarin. The researchers were investigating fragments of adrenocorticotropic hormone (ACTH) that retained neurotropic activity without the hormonal effects on the adrenal glands.
They identified that the ACTH (4-10) fragment possessed cognitive-enhancing properties but was rapidly degraded in the body. By adding a stabilizing Pro-Gly-Pro tripeptide to the C-terminus—the same modification later used in Selank—they created a molecule with dramatically improved stability and bioavailability while maintaining and even enhancing its neurotropic effects.
Semax has been the subject of extensive clinical and preclinical investigation in Russia since the early 1990s, with over three decades of published research examining its interactions with neurotrophic pathways, including BDNF signaling. The peptide's ability to cross the blood-brain barrier and influence multiple neurotrophic pathways has made it a valuable tool in neuroscience research.
Quick Facts
| CAS Number | 80714-61-0 |
|---|---|
| Molecular Formula | C₃₉H₆₃N₁₁O₁₀ |
| Molar Mass | 846.0 g/mol |
| Sequence | 7 amino acids (heptapeptide) |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC verified) |
| Third-Party Testing | Freedom Diagnostics (COA included) |
| Storage | Room temp 3–4 months; refrigerate post-reconstitution |
| Price (from) | $60.00 USD |
| SKU | PF-SEMAX-10MG |
How Semax Works
Preclinical studies have examined Semax's mechanism involving upregulation of neurotrophic factors, modulation of monoaminergic systems, and enhancement of neuroplasticity through multiple receptor and signaling pathways.
Neurotrophic Factor Induction
Semax significantly upregulates BDNF (brain-derived neurotrophic factor), NGF (nerve growth factor), and their receptors TrkB and TrkA. These neurotrophins support neuronal survival, synaptic plasticity, and are critical for learning and memory processes.
Melanocortin System
As an ACTH fragment, Semax interacts with melanocortin receptors (MC3R and MC4R) in the brain. This system modulates attention, arousal, and cognitive flexibility without the peripheral adrenal effects of full-length ACTH.
Dopamine and Serotonin Modulation
Semax influences dopaminergic and serotonergic neurotransmission in limbic and cortical regions. It appears to enhance dopamine synthesis and modulate serotonin turnover, contributing to improved attention and mood regulation in preclinical models.
Anti-Oxidative and Anti-Inflammatory
Research shows Semax has antioxidant properties and can reduce inflammatory cytokine expression in neural tissue. These effects contribute to its neuroprotective capacity under conditions of oxidative stress or ischemia.
Frequently Asked Questions
- What is Semax?
- Semax (CAS 80714-61-0) is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4-10), studied in laboratory settings for its interactions with neurotrophic signaling pathways and neuroprotective mechanisms in preclinical models.
- What is the CAS number for Semax?
- The CAS number for Semax is 80714-61-0.
- What purity is Peptide Foundry's Semax?
- Peptide Foundry's research peptides are manufactured to 99%+ purity. Every batch is verified by an independent third-party laboratory (Freedom Diagnostics) using high-performance liquid chromatography (HPLC) for purity and identity, Limulus amebocyte lysate (LAL) assay for bacterial endotoxin, and inductively coupled plasma mass spectrometry (ICP-MS) for heavy-metal contamination. A Certificate of Analysis is published for every product and batch.
- How should Semax be stored?
- Lyophilized (freeze-dried) peptides are stable at room temperature for 3–4 months. Once reconstituted with bacteriostatic water, store refrigerated (2–8 °C) and use within 30 days. Keep away from direct light and extreme temperatures.
- Does Semax ship with a Certificate of Analysis?
- Yes. Every batch of every product ships with a Certificate of Analysis from Freedom Diagnostics, an independent third-party analytical laboratory. The COA documents HPLC purity, peptide identity, endotoxin testing, and heavy-metals screening.
- Is Semax sold for human use?
- No. All products sold by Peptide Foundry are strictly for in-vitro research and laboratory use only (RUO). They are not intended for human or animal consumption, therapeutic use, or diagnostic application.
Scientific References
- Ashmarin IP, et al. The nootropic drug Semax: a review of its mechanisms of action. Neuroscience and Behavioral Physiology. 2005.
- Dolotov OV, et al. Semax regulates BDNF and trkB expression in the rat hippocampus. Brain Research. 2006. PubMed: 16996037
- Gusev EI, et al. Semax in prevention of disease progress in patients with cerebrovascular insufficiency. Zhurnal Nevrologii i Psikhiatrii. 2005.
- Agapova TY, et al. Effects of Semax on dopamine and serotonin metabolism in rat brain. Doklady Biological Sciences. 2007.
This product is sold strictly for in-vitro research use only (RUO). It is not intended for human or animal consumption, therapeutic use, or diagnostic application.