Selank
A synthetic tuftsin analog studied in laboratory settings for anxiolytic activity and cognitive function
About Selank
Selank (CAS 129954-34-3) is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from tuftsin, studied in laboratory settings for its interactions with anxiolytic and neuroprotective signaling pathways in preclinical models.
Selank was developed in the late 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences, under the direction of Nikolai Myasoedov. The research team was exploring derivatives of tuftsin, an immunomodulatory tetrapeptide naturally found in the body as part of the immunoglobulin G heavy chain.
The scientists added a Pro-Gly-Pro sequence to tuftsin, creating a more stable heptapeptide that could cross biological barriers more effectively. This modification not only preserved the immune-modulating properties of the parent compound but also revealed unexpected effects on the central nervous system, particularly on anxiety-related behaviors.
Selank has been the subject of extensive preclinical and clinical research since its development, with publications spanning anxiolytic signaling, immunomodulatory mechanisms, and neuroprotective pathways. The peptide represents an interesting example of how structural modifications can expand a molecule's biological activities.
Quick Facts
| CAS Number | 129954-34-3 |
|---|---|
| Molecular Formula | C₃₃H₅₇N₁₁O₉ |
| Molar Mass | 751.9 g/mol |
| Sequence | 7 amino acids (heptapeptide) |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC verified) |
| Third-Party Testing | Freedom Diagnostics (COA included) |
| Storage | Room temp 3–4 months; refrigerate post-reconstitution |
| Price (from) | $60.00 USD |
| SKU | PF-SELANK-10MG |
How Selank Works
Preclinical studies have examined Selank's mechanism involving modulation of GABAergic neurotransmission, effects on monoamine systems, and regulation of neurotrophic factors in brain regions associated with anxiety and cognition.
GABAergic Modulation
Selank has been shown to allosterically modulate GABA-A receptors, enhancing inhibitory neurotransmission. This mechanism is similar to benzodiazepines but without the associated sedation, tolerance, or dependence observed in preclinical studies.
Monoamine System Effects
Research indicates Selank influences serotonin and dopamine metabolism in limbic structures. It appears to stabilize the balance of these neurotransmitters, particularly under stress conditions, contributing to its anxiolytic-like effects in research models.
Neurotrophic Factor Expression
Selank has been observed to upregulate brain-derived neurotrophic factor (BDNF) expression in hippocampal regions. BDNF supports neuronal survival, synaptic plasticity, and is implicated in learning and memory processes.
Immunomodulatory Activity
Through its tuftsin-derived core, Selank retains immunomodulatory properties. It influences cytokine expression and immune cell function, suggesting a connection between its immune and CNS effects through neuroimmune pathways.
Frequently Asked Questions
- What is Selank?
- Selank (CAS 129954-34-3) is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from tuftsin, studied in laboratory settings for its interactions with anxiolytic and neuroprotective signaling pathways in preclinical models.
- What is the CAS number for Selank?
- The CAS number for Selank is 129954-34-3.
- What purity is Peptide Foundry's Selank?
- Peptide Foundry's research peptides are manufactured to 99%+ purity. Every batch is verified by an independent third-party laboratory (Freedom Diagnostics) using high-performance liquid chromatography (HPLC) for purity and identity, Limulus amebocyte lysate (LAL) assay for bacterial endotoxin, and inductively coupled plasma mass spectrometry (ICP-MS) for heavy-metal contamination. A Certificate of Analysis is published for every product and batch.
- How should Selank be stored?
- Lyophilized (freeze-dried) peptides are stable at room temperature for 3–4 months. Once reconstituted with bacteriostatic water, store refrigerated (2–8 °C) and use within 30 days. Keep away from direct light and extreme temperatures.
- Does Selank ship with a Certificate of Analysis?
- Yes. Every batch of every product ships with a Certificate of Analysis from Freedom Diagnostics, an independent third-party analytical laboratory. The COA documents HPLC purity, peptide identity, endotoxin testing, and heavy-metals screening.
- Is Selank sold for human use?
- No. All products sold by Peptide Foundry are strictly for in-vitro research and laboratory use only (RUO). They are not intended for human or animal consumption, therapeutic use, or diagnostic application.
Scientific References
- Seredenin SB, et al. Anxiolytic action of the synthetic peptide Selank. Bulletin of Experimental Biology and Medicine. 1998.
- Kozlovskii II, et al. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neuroscience and Behavioral Physiology. 2003. PubMed: 14969422
- Zozulia AA, et al. Effects of Selank on the immunity status in patients with generalized anxiety disorder. Zhurnal Nevrologii i Psikhiatrii. 2008.
This product is sold strictly for in-vitro research use only (RUO). It is not intended for human or animal consumption, therapeutic use, or diagnostic application.