What is the CAS number for DSIP?

The CAS number for DSIP is 62568-57-4.

What purity is Peptide Foundry's DSIP?

Peptide Foundry's research peptides are manufactured to 99%+ purity. Every batch is verified by an independent third-party laboratory (Freedom Diagnostics) using high-performance liquid chromatography (HPLC) for purity and identity, Limulus amebocyte lysate (LAL) assay for bacterial endotoxin, and inductively coupled plasma mass spectrometry (ICP-MS) for heavy-metal contamination. A Certificate of Analysis is published for every product and batch.

How should DSIP be stored?

Lyophilized (freeze-dried) peptides are stable at room temperature for 3–4 months. Once reconstituted with bacteriostatic water, store refrigerated (2–8 °C) and use within 30 days. Keep away from direct light and extreme temperatures.

Does DSIP ship with a Certificate of Analysis?

Yes. Every batch of every product ships with a Certificate of Analysis from Freedom Diagnostics, an independent third-party analytical laboratory. The COA documents HPLC purity, peptide identity, endotoxin testing, and heavy-metals screening.

Is DSIP sold for human use?

No. All products sold by Peptide Foundry are strictly for in-vitro research and laboratory use only (RUO). They are not intended for human or animal consumption, therapeutic use, or diagnostic application.

DSIP

Name: DSIP (Delta Sleep-Inducing Peptide)
Brand: Peptide Foundry
SKU: PF-DSIP-5MG
Price: 55.00 USD
Availability: InStock

A naturally occurring nonapeptide studied in laboratory settings for sleep modulation, stress response, and neuroprotective mechanisms

About DSIP

DSIP (Delta Sleep-Inducing Peptide, CAS 62568-57-4) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit cerebral venous blood during induced sleep. It has been studied in preclinical and clinical models for its interactions with sleep architecture, neuroendocrine signaling, and stress-related pathways.

DSIP was first isolated in 1977 by Swiss researchers Schoenenberger and Monnier from the cerebral venous blood of rabbits during electrically induced sleep. They identified this nonapeptide as a factor associated with the promotion of delta-wave (slow-wave) sleep patterns, giving it the name Delta Sleep-Inducing Peptide.

Following its discovery, DSIP attracted substantial research interest across multiple fields. Studies through the 1980s and 1990s expanded beyond sleep research to explore its interactions with stress-related neuroendocrine pathways, pain modulation systems, and oxidative stress defense mechanisms. Soviet and later Russian research groups, notably Sudakov and colleagues, contributed extensively to understanding DSIP's role in adaptive stress responses.

DSIP has been identified in various tissues including the hypothalamus, limbic structures, and peripheral blood, suggesting broad neuromodulatory roles. While the peptide's receptor and precise signaling pathways continue to be investigated, its involvement in sleep regulation, stress adaptation, and neuroprotective mechanisms has been documented across numerous preclinical and limited clinical studies.

Quick Facts

DSIP Research Specifications
CAS Number	62568-57-4
Molecular Formula	C₃₅H₄₈N₁₀O₁₅
Molar Mass	848.81 g/mol
Sequence	9 amino acids (nonapeptide)
Form	Lyophilized powder
Purity	99%+ (HPLC verified)
Third-Party Testing	Freedom Diagnostics (COA included)
Storage	Room temp 3–4 months; refrigerate post-reconstitution
Price (from)	$55.00 USD
SKU	PF-DSIP-5MG

How DSIP Works

Preclinical studies have examined DSIP's mechanisms involving modulation of sleep-regulating neurotransmitter systems, interaction with neuroendocrine stress pathways, and effects on cellular antioxidant defense in neural tissue models.

Sleep Architecture Modulation

DSIP has been observed in electroencephalographic studies to promote delta-wave (slow-wave) sleep without significantly suppressing REM stages. Research suggests it may act through GABAergic and serotonergic systems in the hypothalamus and brainstem sleep-regulating nuclei to influence sleep stage transitions.

HPA Axis & Stress Adaptation

Laboratory studies have examined DSIP's interactions with the hypothalamic-pituitary-adrenal axis. Research indicates the peptide may modulate ACTH and corticosterone release under stress conditions, potentially contributing to adaptive stress responses and neuroendocrine homeostasis.

Oxidative Stress Defense

Preclinical studies have documented DSIP's effects on antioxidant enzyme activity, including superoxide dismutase and catalase, in neural tissue. Research suggests the peptide may reduce lipid peroxidation markers and protect neuronal cells under conditions of oxidative stress.

Opioid System Interactions

Studies have investigated DSIP's interactions with endogenous opioid systems. Research indicates the peptide may influence met-enkephalin levels and interact with opioid receptor signaling, contributing to its observed effects on nociceptive processing in preclinical pain models.

Frequently Asked Questions

What is DSIP?: DSIP (Delta Sleep-Inducing Peptide, CAS 62568-57-4) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit cerebral venous blood during induced sleep. It has been studied in preclinical and clinical models for its interactions with sleep architecture, neuroendocrine signaling, and stress-related pathways.
What is the CAS number for DSIP?: The CAS number for DSIP is 62568-57-4.
What purity is Peptide Foundry's DSIP?: Peptide Foundry's research peptides are manufactured to 99%+ purity. Every batch is verified by an independent third-party laboratory (Freedom Diagnostics) using high-performance liquid chromatography (HPLC) for purity and identity, Limulus amebocyte lysate (LAL) assay for bacterial endotoxin, and inductively coupled plasma mass spectrometry (ICP-MS) for heavy-metal contamination. A Certificate of Analysis is published for every product and batch.
How should DSIP be stored?: Lyophilized (freeze-dried) peptides are stable at room temperature for 3–4 months. Once reconstituted with bacteriostatic water, store refrigerated (2–8 °C) and use within 30 days. Keep away from direct light and extreme temperatures.
Does DSIP ship with a Certificate of Analysis?: Yes. Every batch of every product ships with a Certificate of Analysis from Freedom Diagnostics, an independent third-party analytical laboratory. The COA documents HPLC purity, peptide identity, endotoxin testing, and heavy-metals screening.
Is DSIP sold for human use?: No. All products sold by Peptide Foundry are strictly for in-vitro research and laboratory use only (RUO). They are not intended for human or animal consumption, therapeutic use, or diagnostic application.

Scientific References

Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (sleep)-inducing peptide. Proceedings of the National Academy of Sciences. 1977;74(3):1282-1286. PubMed: 265572
Sudakov KV, Coghlan JP, Kotov AV, et al. Delta sleep-inducing peptide sequelae: a review of experimental and clinical studies. International Journal of Neuroscience. 1995;83(3-4):235-250.
Prudchenko IA, Starostina MV, Bhargava KP. Delta sleep-inducing peptide: structure-activity relationships. Peptides. 1995;16(6):1073-1078. PubMed: 8532591
Lysenko AV, Uskova NI. The mechanisms of DSIP neuroprotective action in conditions of oxidative stress caused by acute emotional stress. Neuroscience and Behavioral Physiology. 2007;37(7):671-675.

This product is sold strictly for in-vitro research use only (RUO). It is not intended for human or animal consumption, therapeutic use, or diagnostic application.