CJC-1295 / Ipamorelin Blend
A dual-peptide blend studied in laboratory and clinical settings for growth hormone secretion and body composition
About CJC-1295 / Ipamorelin Blend
CJC-1295 / Ipamorelin is a peptide blend researched for its dual-mechanism effects on GH secretion pathways—combining GHRH-analog signaling (CJC-1295) with selective ghrelin receptor activation (Ipamorelin) in preclinical and clinical models. The combination has been studied for effects on GH pulse amplitude and frequency.
This blend brings together two peptides with very different origin stories. CJC-1295 was developed by a Canadian biotech company called ConjuChem Biotechnologies in the early 2000s. They were trying to create a longer-lasting version of the body's natural growth hormone-releasing hormone—something researchers could use without needing constant dosing.
Ipamorelin came from a different direction entirely. Scientists at Novo Nordisk in Denmark created it in the late 1990s while looking for a cleaner way to stimulate growth hormone release. What made Ipamorelin special was its selectivity—it could trigger GH release without affecting other hormones like cortisol, which had been a problem with earlier compounds.
Researchers eventually started combining these two peptides to see if they would work better together. In preclinical models, CJC-1295 has been studied for its effects on GH pulse amplitude, while Ipamorelin has been researched for its influence on pulse frequency—a dual mechanism that makes the combination particularly interesting for GH-axis research.
Today, the CJC-1295 + Ipamorelin combination is one of the most studied peptide blends for growth hormone research. Labs around the world use it to explore questions about metabolism, aging, and body composition.
Quick Facts
| CJC-1295 CAS | 863288-34-0 |
|---|---|
| CJC-1295 Formula | C₁₆₅H₂₇₁N₄₇O₄₆ |
| CJC-1295 Molar Mass | 3647.28 g/mol |
| Ipamorelin CAS | 170851-70-4 |
| Ipamorelin Formula | C₃₈H₄₉N₉O₅ |
| Ipamorelin Molar Mass | 711.85 g/mol |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC verified) |
| Third-Party Testing | Freedom Diagnostics (COA included) |
| Storage | Room temp 3–4 months; refrigerate post-reconstitution |
| Price (from) | $85.00 USD |
| SKU | PF-CJC1295IPAM-5MG5MG |
How CJC-1295 / Ipamorelin Blend Works
In clinical studies, CJC-1295 has been observed to produce sustained, dose-dependent increases in GH and IGF-1 levels via GHRH receptor signaling. Ipamorelin has been characterized as a selective ghrelin receptor agonist that stimulates GH pulse frequency without cortisol or prolactin stimulation. Together, this combination is studied for dual-mechanism modulation of the GH-IGF-1 axis.
GHRH Receptor Amplification
CJC-1295 binds to GHRH receptors on pituitary somatotroph cells, activating adenylyl cyclase and increasing intracellular cAMP. Clinical studies have observed amplification of GH pulse magnitude while preserving natural pulsatile rhythm. The DAC modification extends half-life to 6-8 days, enabling sustained GH elevation in research models.
Selective Ghrelin Mimetic Action
Ipamorelin selectively activates GHS-R1a receptors on pituitary cells. Studies have noted that this selectivity results in GH release without corresponding cortisol or prolactin stimulation. This selectivity profile has made Ipamorelin a widely used research tool for investigating GH secretagogue signaling.
IGF-1 Signaling Cascade
Elevated GH stimulates hepatic production of IGF-1, which activates the PI3K/Akt and MAPK pathways in muscle, bone, and connective tissue. These pathways have been studied for their roles in protein synthesis, cellular proliferation, and tissue repair signaling.
Metabolic Research Pathways
Preclinical research has examined how sustained GH elevation interacts with lipolytic pathways, including hormone-sensitive lipase activation in adipose tissue. Studies have also investigated effects on glucose uptake in muscle tissue and fuel utilization patterns.
Frequently Asked Questions
- What is CJC-1295 / Ipamorelin Blend?
- CJC-1295 / Ipamorelin is a peptide blend researched for its dual-mechanism effects on GH secretion pathways—combining GHRH-analog signaling (CJC-1295) with selective ghrelin receptor activation (Ipamorelin) in preclinical and clinical models. The combination has been studied for effects on GH pulse amplitude and frequency.
- What are the components of the CJC-1295 / Ipamorelin Blend?
- The CJC-1295 / Ipamorelin Blend contains CJC-1295 (863288-34-0) and Ipamorelin (170851-70-4).
- What purity is Peptide Foundry's CJC-1295 / Ipamorelin Blend?
- Peptide Foundry's research peptides are manufactured to 99%+ purity. Every batch is verified by an independent third-party laboratory (Freedom Diagnostics) using high-performance liquid chromatography (HPLC) for purity and identity, Limulus amebocyte lysate (LAL) assay for bacterial endotoxin, and inductively coupled plasma mass spectrometry (ICP-MS) for heavy-metal contamination. A Certificate of Analysis is published for every product and batch.
- How should CJC-1295 / Ipamorelin Blend be stored?
- Lyophilized (freeze-dried) peptides are stable at room temperature for 3–4 months. Once reconstituted with bacteriostatic water, store refrigerated (2–8 °C) and use within 30 days. Keep away from direct light and extreme temperatures.
- Does CJC-1295 / Ipamorelin Blend ship with a Certificate of Analysis?
- Yes. Every batch of every product ships with a Certificate of Analysis from Freedom Diagnostics, an independent third-party analytical laboratory. The COA documents HPLC purity, peptide identity, endotoxin testing, and heavy-metals screening.
- Is CJC-1295 / Ipamorelin Blend sold for human use?
- No. All products sold by Peptide Foundry are strictly for in-vitro research and laboratory use only (RUO). They are not intended for human or animal consumption, therapeutic use, or diagnostic application.
Scientific References
- Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006;91(12):4792-4797. PubMed: 17018654
- Teichman SL, Neale A, Lawrence B, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. PubMed: 16352683
- Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561. PubMed: 9849822
- Gobburu JV, Agersø H, Jusko WJ, Ynddal L. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. 1999;16(9):1412-1416. PubMed: 10496658
This product is sold strictly for in-vitro research use only (RUO). It is not intended for human or animal consumption, therapeutic use, or diagnostic application.