BPC-157
A 15-amino-acid synthetic peptide studied in laboratory settings for tissue regeneration and healing mechanisms
About BPC-157
BPC-157 (Body Protection Compound-157, CAS 137525-51-0) is a 15-amino-acid synthetic peptide originally isolated from human gastric juice. It has been studied in preclinical models for effects on tissue regeneration pathways and inflammatory signaling cascades.
BPC-157, short for "Body Protection Compound-157," was first identified during research on human gastric juice in the early 1990s. Croatian researchers at the University of Zagreb, led by Dr. Predrag Sikirić, originally isolated this sequence from a larger protective protein found naturally in the stomach—which is where the "Body Protection Compound" name originated.
Over the past three decades, BPC-157 has become one of the more extensively studied peptides in preclinical research. Hundreds of peer-reviewed publications have examined its interactions with various biological systems, including nitric oxide pathways, growth factor signaling, and angiogenic processes.
Research interest has spanned multiple biological systems—from gastrointestinal and musculoskeletal models to neurological and vascular studies. While preclinical data has accumulated over 30+ years, it's worth noting that human clinical trials remain limited, and most published findings come from animal or in vitro studies.
Quick Facts
| CAS Number | 137525-51-0 |
|---|---|
| Molecular Formula | C₆₂H₉₈N₁₆O₂₂ |
| Molar Mass | 1419.55 g/mol |
| Sequence | 15 amino acids |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC verified) |
| Third-Party Testing | Freedom Diagnostics (COA included) |
| Storage | Room temp 3–4 months; refrigerate post-reconstitution |
| Price (from) | $55.00 USD |
| SKU | PF-BPC157-10MG |
How BPC-157 Works
Preclinical studies have examined BPC-157's interactions with several molecular pathways in cell culture and animal models. Published investigations suggest involvement in angiogenesis-related signaling, vascular function, cellular migration processes, and inflammatory response modulation.
VEGFR2 Activation & Angiogenesis
In preclinical models, BPC-157 has been observed to bind to VEGFR2 on endothelial cells, initiating a phosphorylation cascade that activates MAPK/ERK and PI3K/Akt pathways. Studies suggest this may stimulate endothelial cell proliferation, migration, and tube formation.
Nitric Oxide System Modulation
Preclinical research indicates BPC-157 has been associated with upregulation of endothelial nitric oxide synthase (eNOS) expression in laboratory models. Published studies suggest this may increase nitric oxide (NO) bioavailability, with downstream effects on vascular tone and tissue perfusion.
FAK Signaling & Cell Migration
Laboratory studies have observed that BPC-157 may activate Focal Adhesion Kinase (FAK) through phosphorylation at Tyr397, potentially triggering recruitment of Src family kinases and downstream effectors that influence cellular migration toward sites of tissue damage.
Growth Factor Interactions
Research has investigated BPC-157's interactions with various growth factors including EGF, FGF, and TGF-β pathways. These studies have examined potential effects on cellular proliferation, extracellular matrix remodeling, and tissue regeneration processes.
Frequently Asked Questions
- What is BPC-157?
- BPC-157 (Body Protection Compound-157, CAS 137525-51-0) is a 15-amino-acid synthetic peptide originally isolated from human gastric juice. It has been studied in preclinical models for effects on tissue regeneration pathways and inflammatory signaling cascades.
- What is the CAS number for BPC-157?
- The CAS number for BPC-157 is 137525-51-0.
- What purity is Peptide Foundry's BPC-157?
- Peptide Foundry's research peptides are manufactured to 99%+ purity. Every batch is verified by an independent third-party laboratory (Freedom Diagnostics) using high-performance liquid chromatography (HPLC) for purity and identity, Limulus amebocyte lysate (LAL) assay for bacterial endotoxin, and inductively coupled plasma mass spectrometry (ICP-MS) for heavy-metal contamination. A Certificate of Analysis is published for every product and batch.
- How should BPC-157 be stored?
- Lyophilized (freeze-dried) peptides are stable at room temperature for 3–4 months. Once reconstituted with bacteriostatic water, store refrigerated (2–8 °C) and use within 30 days. Keep away from direct light and extreme temperatures.
- Does BPC-157 ship with a Certificate of Analysis?
- Yes. Every batch of every product ships with a Certificate of Analysis from Freedom Diagnostics, an independent third-party analytical laboratory. The COA documents HPLC purity, peptide identity, endotoxin testing, and heavy-metals screening.
- Is BPC-157 sold for human use?
- No. All products sold by Peptide Foundry are strictly for in-vitro research and laboratory use only (RUO). They are not intended for human or animal consumption, therapeutic use, or diagnostic application.
Scientific References
- Chang CH, et al. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014. PubMed: 25415472
- Staresinic M, et al. BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocyte growth and VEGF secretion. Journal of Orthopaedic Research. 2003. PubMed: 14554208
- Sikiric P, et al. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Current Pharmaceutical Design. 2011. PubMed: 21548867
- Sikiric P. The effect of pentadecapeptide BPC 157 on gastrointestinal tract. Journal of Physiology and Pharmacology. 2013. PubMed: 24304574
This product is sold strictly for in-vitro research use only (RUO). It is not intended for human or animal consumption, therapeutic use, or diagnostic application.